• Users Online: 30
  • Print this page
  • Email this page
Year : 2016  |  Volume : 4  |  Issue : 3  |  Page : 46-51

Newer oral anti diabetic drugs, are they useful to Indian Diabetics compared to the existing drugs


Correspondence Address:
Mala Dharmalingam
Director, Bangalore Endocrinology and Diabetes Research Center

Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2666-1802.258523

Rights and Permissions

There are a number of new oral anti diabetic drugs, available for the treatment of Type 2 diabetes mellitus. These include the Dipeptidyl peptidase 4 Inhibitors (DPP4I) and the Sodium-Glucose Cotransporter 2Inhibitors(SGLT 2 inhibitors). The pathophysiologic mechanisms of Type 2 Diabetes have emerged from the triumvirate of insulin resistance at the level of the muscle, fat cell and the liver, insulin deficiency at the level of the beta cell of the pancreas and increased hepatic glucose output from the liver, to the ominous octet which now includes pathophysiologic mechanism at different levels of alpha cell, brain, kidney, gut etc. There are now drugs working at these mechanisms. These include the DPP4I that, work at the level of the incretin system,suppress glucagon and increase insulin. Bromocriptine has a sympatholytic D2 Dopamine agonist working centrally and resetting the dopaminergic and sympathetic tone within the central nervous system. The most recent are the SGLT2 inhibitors that work at the level of the kidney preventing reabsorption of glucose. The effect of these drugs on the glycemic control, durability, the cardiovascular outcomes and effect on cancer are the considerations of this review. This will allow the physician to make a calculated decision on which oral medication to use for the diabetic patient.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded87    
    Comments [Add]    

Recommend this journal