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Year : 2019  |  Volume : 7  |  Issue : 4  |  Page : 109-116

Association between serum cholinesterase levels and clinical outcome in patients of organophosphorus compound poisoning – One-year hospital-based longitudinal study

Department of General Medicine, J. N. Medical College, Belagavi, Karnataka, India

Correspondence Address:
Dr. Vivek Veereshkumar Shirol
B – 7/1, Staff Quarters, JNMC Campus, Nehru Nagar, Belagavi - 590 010, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/AJIM.AJIM_46_19

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Background and Objectives: The activity of serum cholinesterase (SChE) decreases in organophosphate compound poisoning. This study was aimed to evaluate SChE levels as a prognostic marker for patients with organophosphorus (OP) poisoning. Materials and Methods: The present 1-year hospital-based longitudinal study was done on a total of 85 patients admitted with OP compound poisoning in the Department of Medicine, Hospital and Medical Research Centre, from January 2014 to December 2014. The estimation of pseudocholinesterase levels was done at the time of admission, on the 5th day and at the time of discharge. Results: Maximum number of cases had age <30 years (55.29%), and the mean age was 35.28 ± 15.34 years. There was male preponderance with a male to female ratio of 2.4:1. The most commonly consumed compound was malathion (24.71%). Majority of the patients (62.35%) presented after 3–6 h of consumption. The most common symptom was vomiting (87.06%), and peradeniya OP poisoning score revealed moderate intoxication in 58.82% of the patients. SChE levels were profoundly low (≤2500 U/L) in 62.35% of the patients at admission, 65.33% on 5th day, and 62.71% at the time of discharge. Acute renal failure was the most common complication, noted in 23.08% of the patients. Mortality was noted in 15.29% of the patients, and intermediate syndrome was the most common cause (30.77%). Conclusion: There is a positive association of SChE with hospital stay (1st day levels and serial estimation); requirement of ventilatory support (1st day levels); and outcome (serial estimation).

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