• Users Online: 195
  • Print this page
  • Email this page
REVIEW ARTICLE
Year : 2022  |  Volume : 10  |  Issue : 2  |  Page : 60-68

Sepsis-associated acute kidney injury and the need for renal replacement therapy: A physician's perspective


Department of Nephrology, Command Hospital Air Force, Bengaluru, Karnataka, India

Correspondence Address:
Dr. Vijoy Kumar Jha
Command Hospital Air Force, PO-Agram, Bengaluru - 560 007, Karnatakaa
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ajim.ajim_30_21

Rights and Permissions

Sepsis associated acute kidney injury is a very common complication and carries unacceptable mortality in the setting of critical illness. Physicians should be very prompt to recognise it an an eartly stage, as providing supporting care early will limit further insults to the kidney. By the time patients seek medical attention, acute kidney injury has already happened. Microvascular dysfunction, inflammation, and metabolic reprogramming are three mechanisms that have been proposed to explain the pathophysiology of acute kidney injury associated with sepsis. The role of early renal replacement therapy /blood purification technique is still controversial. We need more studies to better understand the complex pathophysiology of this complication and translate these findings into potential treatment strategies. In this review, new definitions of sepsis and acute kidney injury, risk factors, pathophysiology and management strategies of sepsis- associated acute kidney injury are being discussed.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1398    
    Printed57    
    Emailed0    
    PDF Downloaded149    
    Comments [Add]    

Recommend this journal