• Users Online: 391
  • Print this page
  • Email this page
Year : 2022  |  Volume : 10  |  Issue : 3  |  Page : 195-202

Changing Trends of adenocarcinoma among other nonperipheral lung tumors in smokers and nonsmokers: A Tertiary care center's experience

1 Department of Pulmonary Medicine, Vydehi Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka, India
2 Department of Pathology, Government Medical College, Anantnag, Jammu and Kashmir, India

Correspondence Address:
Dr. Ajit Harsha
Department of Pulmonary Medicine, Vydehi Institute of Medical Sciences and Research Centre, 82, Near BMTC 18th Depot, Vijayanagar, Nallurhalli, Whitefield, Bengaluru - 560 066, Karnataka
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ajim.ajim_88_21

Rights and Permissions

Background: Globally, modern lifestyles and the increasing incidence of lung cancer have changed the histopathological presentation of lung cancer to the point that it has reached epidemic proportions. It is well known that tobacco smokers are more prone to lung cancer. Nonsmokers are no exception. We conducted this study to determine if primary lung cancer is increasing in nonsmokers and examine the differences in clinicopathological patterns and disease staging between smokers and nonsmokers. Objective: (1) Comparing the occurrence of nonperipheral lung tumors in smokers and nonsmokers, (2) to determine whether bronchogenic carcinoma in smokers and nonsmokers exhibited the same histopathological shift, (3) a comparison of lung cancer in smokers and nonsmokers based on clinical and radiological findings. Materials and Methods: A prospective study in Pulmonary Medicine was conducted over 7 years from August 2012 to January 2020. All adult patients were screened with a detailed history and risk factors. Histopathological analysis was performed on patients with X-ray findings that appeared to be a mass or collapse caused by endobronchial growth, as well as on patients who were clinically, radiologically, and bronchoscopically suspicious for malignancy. Results: The study reports that out of the 386 cases of bronchogenic carcinoma, 295 (76.4%) were between 46 and 70 years of age, 282 (73.05%) were male, 250 (85%) smokers, and 104 (27%) females, 44 (14.9%) smokers. Smokers outnumbered nonsmokers by a ratio of 3.1:1. In 257 patients, fever was the most common symptom, followed by hemoptysis in 245 patients. Mass lesion was the most common radiological finding in 245 (63.4%) patients. Squamous cell carcinoma 123 patients (43.6%), Adenocarcinoma 107 patients (37.9%) and small cell carcinoma 35 patients (12.4%) were more common in males, while adenocarcinoma patients 48 (46.1%), squamous cell carcinoma 36 patients (34.6%) and small cell carcinoma 12 patients (11.5%) were more common in females. Conclusion: Majority of elderly patients have an increased risk of developing malignancy, as shown by this study. Smokers are still more likely to develop primary lung cancer than nonsmokers. Squamous cell carcinomas constituted a greater proportion of all histopathological types than adenocarcinomas. Adenocarcinomas are more likely to develop centrally during their later stages. The majority of adenocarcinoma patients presented at the terminal stage and were not smokers.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded20    
    Comments [Add]    

Recommend this journal