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ORIGINAL ARTICLE
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Association between neutrophil-to-lymphocyte ratio and severity of coronary artery disease


 Department of General Medicine, Mallige Medical Centre, Bengaluru, Karnataka, India

Correspondence Address:
Dilmo Yeldo,
Mallige Medical Centre, 31/32, Crescent Road, Madhava Nagar, Gandhi Nagar, Bengaluru - 560 001, Karnataka
India
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ajim.ajim_92_22

Background: Atherosclerosis is a complex inflammatory disease. The neutrophil-to-lymphocyte ratio (NLR) is a systemic inflammatory marker that is correlated with adverse cardiovascular outcomes. Aim: The aim of this study was to investigate the association between NLR and severity of coronary artery disease. Study Design and Methodology: It is a hospital-based observational study. A total of 90 participants were included in the study. All the participants were divided into three groups based on the result of coronary angiography report using both Syntax and Gensini scores. NLR was calculated as the ratio of neutrophil count to lymphocyte count. Results: The NLR was evaluated for the severity of coronary arterial stenosis. A significantly higher (Chi-square value [50.35], df [2], P < 0.001) NLR ratio was seen in patients with severe coronary stenosis based on Syntax scoring. A significantly higher (Chi-square value [60.93], df [2], P < 0.001) NLR ratio was seen in patients with severe coronary arterial stenosis based on Gensini scoring. In logistic regression analyses, NLR was an independent predictor of coronary artery disease. An NLR of 2.15 or higher predicted the severity of coronary artery disease. Conclusion: In this study, it was found that NLR was significantly elevated in patients with significant coronary artery stenosis estimated by both Syntax and Gensini scores.


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    -  Gordhanbhai PS
    -  Ravindra T S
    -  Yeldo D
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