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  Access statistics : Table of Contents
   2016| July-September  | Volume 4 | Issue 3  
    Online since May 17, 2019

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Ranitidine Induced Anaphylaxis
Nandakumar Bhat, Sudha Vidyasagar, Rohit Reddy, Avinash Holla
July-September 2016, 4(3):36-37
Anaphylaxis is a life threatening emergency requiring emergency management and prompt detection of the inciting agent to prevent future episodes. Ranitidine most commonly prescribed drug in yester-years for GERD, peptic ulcer disease, gastritis and preoperative prophylaxis for aspiration, is rarely associated with allergy and anaphylaxis. Anaphylaxis is most commonly reported with the use of intravenous ranitidine. We report a case of anaphylactic reaction to ranitidine tablet in a 51 year old gentleman. Patient was treated successfully and discharged with caution to avoid ranitidine exposure in future
[ABSTRACT]   Full text not available  [PDF]
  568 89 -
Newer oral anti diabetic drugs, are they useful to Indian Diabetics compared to the existing drugs
Mala Dharmalingam
July-September 2016, 4(3):46-51
There are a number of new oral anti diabetic drugs, available for the treatment of Type 2 diabetes mellitus. These include the Dipeptidyl peptidase 4 Inhibitors (DPP4I) and the Sodium-Glucose Cotransporter 2Inhibitors(SGLT 2 inhibitors). The pathophysiologic mechanisms of Type 2 Diabetes have emerged from the triumvirate of insulin resistance at the level of the muscle, fat cell and the liver, insulin deficiency at the level of the beta cell of the pancreas and increased hepatic glucose output from the liver, to the ominous octet which now includes pathophysiologic mechanism at different levels of alpha cell, brain, kidney, gut etc. There are now drugs working at these mechanisms. These include the DPP4I that, work at the level of the incretin system,suppress glucagon and increase insulin. Bromocriptine has a sympatholytic D2 Dopamine agonist working centrally and resetting the dopaminergic and sympathetic tone within the central nervous system. The most recent are the SGLT2 inhibitors that work at the level of the kidney preventing reabsorption of glucose. The effect of these drugs on the glycemic control, durability, the cardiovascular outcomes and effect on cancer are the considerations of this review. This will allow the physician to make a calculated decision on which oral medication to use for the diabetic patient.
[ABSTRACT]   Full text not available  [PDF]
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Serum Cystatin C concentration levels as a marker of acute Kidney injury in critically ill Patients - A cross sectional study
Veena P Munavalli, AJ Dhumale, VA Kothiwale
July-September 2016, 4(3):9-14
Background and objectives: Acute kidney injury (AKI) is a common complication in patients admitted to the Intensive care unit (ICU). AKI is diagnosed based on increase of serum creatinine (Sr. Creatinine). But minor changes of Sr. Creatinine, as typically seen early in AKI, may already reflect substantial decline in GFR, Hence there is a need of an early and more reliable marker of AKI. Studies have shown that Serum Cystatin C (Sr. Cystatin C) is one such marker. Hence this study was undertaken to assess Sr. Cystatin C levels as a marker of AKI in critically ill patients. Methodology: A cross sectional study was conducted on patients admitted in the Medical Intensive Care Unit, during the period of January 2010 to December 2010. 50 patients were studied. All necessary investigations were done to make etiological diagnosis at admission. Sr. Cystatin C and Sr. Creatinine levels were determined at admission (first reading) and levels of Cystatin C and Creatinine after the patient developed AKI, were considered as second reading. Results were analyzed. Results: In this cross-sectional study, there were 33 (66%) males and 17 (34%) females. 18 (36%) patients had primary gastrointestinal disease, 18 (36%) had respiratory disease and 6 (12%) patients had snake bite. The mean Sr. Creatinine and Sr. Cystatin C values in AKI patients were 1.86 mg/dL and 3.14 mg/L respectively. The mean Sr. Creatinine and Sr. Cystatin C values in patients without AKI were 0.68 mg/dL and 0.73 mg/L respectively. The sensitivity, specificity, PPV, NPV of Sr. Creatinine for second reading was 78.57%, 100%, 100%, 78.57% respectively and the sensitivity, specificity, PPV, NPV for second reading of Sr. Cystatin C was 100%. Conclusion: Sr. Creatinine was normal in some patients with AKI whereas Sr. Cystatin C was high indicating that Sr. Cystatin C is more reliable marker than Sr.Creatinine.
[ABSTRACT]   Full text not available  [PDF]
  508 84 -
Acute Fulminant Hepatic Failure Due To Primary Dengue
Dnyanesh N Morkar, Rekha S Patil, Pooja Motimath, C Prudhavi
July-September 2016, 4(3):38-40
Dengue Fever (DF) is rarely considered as a cause of acute hepatic failure and only a few case reports of acute hepatic failure and encephalopathy occurring in DF in adults are available. Here we report the case of a 23 year old previously healthy male who presented to the outpatient department with history of fever and chills since 2 days and 1 episode of hematuria. The patient was further investigated and was diagnosed as dengue positive, following a 2 days of hospital stay he developed altered sensorium. He was admitted and managed in the ICU with supportive care and platelet transfusion. Further investigations were suggestive of acute hepatic failure. With treatment he made a significant clinical and biochemical improvement and was discharged after 8 days of hospital stay.
[ABSTRACT]   Full text not available  [PDF]
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Management of portal hypertensive bleeding
B Vishwanath Tantry
July-September 2016, 4(3):15-23
Bleeding gastro-oesophageal varices is a major complication of cirrhosis and carries a high mortality. Major cause of death is the severity of the underlying disease. Patient with suspected variceal haemorrhage should undergo prompt resuscitation and early endoscopy. A combination of vasoactive drugs and endoscopic therapy gives the best results. Endoscopic variceal ligation is the endoscopic therapy of choice for oesophageal varices. For gastric varices, glue injection with 2% cyanoacrylate is the most cost effective therapy. In uncontrollable haemorrhage from oesophageal varices, emergency covered stent placement in oesophagus may be life saving. Use of covered TIPS should be considered in medical failure for both oesophageal and gastric varices. Balloon occluded retrograde transvenous obliteration is an emerging therapy for gastric varices. Re-bleeding is best prevented by a combination of beta blockers and endoscopic variceal ligation.
[ABSTRACT]   Full text not available  [PDF]
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Journal Watch - Feb 1st 2016 - May 15th, 2016
BV Murali Mohan
July-September 2016, 4(3):26-31
The number of publications in the medical journals are increasing daily, and choosing articles for more detailed reading and their findings for adoption is becoming an ever more difficult task. This article attempts to summarise for the benefit of readers some important papers in the areas of infectious diseases and diabetes, published since the last issue of the JIM3R.
[ABSTRACT]   Full text not available  [PDF]
  441 86 -
Cryptococcal Meningitis with secondary Cutaneous Cryptococcoma
K Akhila Rao, Nagappa Handagal
July-September 2016, 4(3):41-43
Cryptococcosis is a potentially fatal fungal disease caused by variants of Cryptococcus neoformans species. The disease is mostly seen in immunodeficiency states particularly among those infected with human immunodeficiency virus (HIV). The CNS is the most common site of disseminated cryptococcal infection. We present an interesting case of HIV positive patient presenting as secondary cutaneous cryptococcoma with meningitis which is seen in 10-20% of cases and indicates poor prognosis.
[ABSTRACT]   Full text not available  [PDF]
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Sudden Unexpected Death In Epilepsy Patients(SUDEP)
Vasantha Kamath, Mahitha Chilukuri
July-September 2016, 4(3):33-35
SUDEP is the foremost among the causes of premature death associated with epilepsy that deserve special attention because it may be preventable. This entity has received increased attention in recent years, given that its unanticipated occurrence is highly traumatic to the families of those affected. We report a case of a 35 year old male who presented with recurrent epilepsy and died under unforeseen circumstances.
[ABSTRACT]   Full text not available  [PDF]
  412 86 -
Biomarkers in AKI - Have we found a Renal Troponin?
Girish Namagondlu, Sundar Sankaran
July-September 2016, 4(3):7-8
Full text not available  [PDF]
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ECG Diagnosis
Suresh V Sagarad, Swetha R Lakshetty
July-September 2016, 4(3):24-25
Full text not available  [PDF]
  323 70 -
Radiological Diagnosis
Raghavendra Bhat
July-September 2016, 4(3):45-45
Full text not available  [PDF]
  288 74 -
Yellapragada Subbarao
M Ravikeerthy
July-September 2016, 4(3):55-55
Full text not available  [PDF]
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Dr. M. G. Desai
Shivaraj Alashetty
July-September 2016, 4(3):52-52
Full text not available  [PDF]
  265 72 -
CT Diagnosis
July-September 2016, 4(3):44-44
Full text not available  [PDF]
  263 72 -
Pictorial CME
Ramesh jois
July-September 2016, 4(3):32-32
Full text not available  [PDF]
  251 81 -
Dr D Rama Rao
M Premanath, S Samappa
July-September 2016, 4(3):53-53
Full text not available  [PDF]
  269 62 -
M Premanath
July-September 2016, 4(3):6-6
Full text not available  [PDF]
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